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You are here:Home » Antibodies » Abs to Carbohydrates, Glycoproteins » Anti -GRIP1 Associated Protein 1 (GRASP-1, GRASP)

Anti -GRIP1 Associated Protein 1 (GRASP-1, GRASP)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
PDZ domain-containing proteins, such as PSD-95 and GRIP are thought to play key roles in glutamate receptor plasticity. GRIP-associated proteins (GRASPs) that bind to distinct PDZ domains within GRIP also play key roles in regulation of glutamate receptor function. GRASP-1 is a neuronal rasGEF associated with GRIP and AMPA receptors in vivo. Recent work suggests that GRASP-1 may regulate neuronal ras signaling and contribute to the regulation of AMPA receptor distribution by NMDA receptor activity.
Applications:
Western Blot: 1:1000
Optimal dilutions should be determined by each laboratory for each application.
Catalog #G8970-66
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceRat
FormSupplied as a liquid in 10mM HEPES (pH 7.5), 150mM sodium chloride, 100ug/ml BSA and 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenPeptide corresponding to amino acid residues from the C-terminal region of rat GRASP, conjugated to keyhole limpet hemocyanin (KLH)
SpecificitySpecific for the 95kD GRASP in Western Blots of rat cerebellar lysates. Species Crossreactivity: Human and mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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