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You are here:Home » Molecular Biology » Growth Factors-GDF » Growth and Differentiation Factor 5, 382-501aa, Recombinant, Human (GDF5)

Growth and Differentiation Factor 5, 382-501aa, Recombinant, Human (GDF5)

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Specifications

Growth differentiation factor 5(GDF-5) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This protein plays a role in chondrogenesis and chondrocyte metabolism, tendon and ligament tissue formation, and bone repair. It also increases the survival of neurones that respond to a neurotransmitter called dopamine, and is a potential therapeutic molecule associated with Parkinson's disease.
Catalog #G8989-45B
GDF-5, fused to His-tag at N-terminus, was expressed as insoluble protein aggregate in E. coli.
Amino Acid SequenceMGSSHHHHHH SSGLVPRGSH MAPLATRQGK RPSKNLKARC SRKALHVNFK DMGWDDWIIA PLEYEAFHCE GLCEFPLRSH LEPTNHAVIQ TLMNSMDPES TPPTCCVPTR LSPISILFID SANNVVYKQY EDMVVESCGC R
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight15.8kD
SourceE. coli
Purity95% (SDS-PAGE). Endotoxin: 1EU/ug (LAL)
Concentration~0.5mg/ml
FormSupplied as a liquid in 10mM sodium citrate, pH 3.5, 10% glycerol
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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