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Growth and Differentiation Factor 5, 382-501aa, Recombinant, Human (GDF5)
Growth and Differentiation Factor 5, 382-501aa, Recombinant, Human (GDF5)
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| Growth differentiation factor 5(GDF-5) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This protein plays a role in chondrogenesis and chondrocyte metabolism, tendon and ligament tissue formation, and bone repair. It also increases the survival of neurones that respond to a neurotransmitter called dopamine, and is a potential therapeutic molecule associated with Parkinson's disease. | | | Catalog # | G8989-45B | | Source | GDF-5, fused to His-tag at N-terminus, was expressed as insoluble protein aggregate in E.coli. | | Molecular Weight | 15.8kD (141aa) | | AA Sequence | MGSSHHHHHH SSGLVPRGSH MAPLATRQGK RPSKNLKARC SRKALHVNFK DMGWDDWIIA PLEYEAFHCE GLCEFPLRSH LEPTNHAVIQ TLMNSMDPES TPPTCCVPTR LSPISILFID SANNVVYKQY EDMVVESCGC R | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Molecular Weight | 15.8kD | | Source | His-tagged, Recombinant, E. coli | | Purity | 95% (SDS-PAGE) | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in 10mM sodium citrate, pH 3.5, 10% glycerol. | | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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