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You are here:Home » Antibodies » Abs to GTPase, Rab, Ras, Rho Proteins » Anti -GTPase Activating Rap/RanGAP Domain-like 1 (GARNL1, DKFZp566D133, GRIPE, KIAA0884, TULIP1)

Anti -GTPase Activating Rap/RanGAP Domain-like 1 (GARNL1, DKFZp566D133, GRIPE, KIAA0884,
TULIP1)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B
GARNL1 (GTPase activating Rap/Ran-GAP domain-like 1), contains one Rap-GAP domain. It is expressed during embryogenesis with E12. During development, GARNL1 expression decreases, persisting at high levels only in neurons of the adult brain. GARNL1 localizes to the cytoplasm where it may play a role regulating GTP hydrolysis of proteins such as Ran and Rap. GARNL1 is imported to the nucleus via dimerization with E12 and interacts with the HLH region of E12 and may function to negatively regulate the transcription of E12-dependent downstream target genes. This suggests that at least a portion of the function of GARNL1 is dependent upon its association with E12. GARNL1 may also associate with other HLH proteins and influence a variety of HLH signaling cascades. In adult brain, GARNL1 activity does not involve E12 and therefore it may serve a different function in developed neural tissue.
Catalog #G9006-40
ApplicationsSuitable for use in Western Blot and Dot Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No8C170
HostMouse
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a sterile-filtered liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenPartial sequence of recombinant full-length protein to human GTPase Activating Rap/RanGAP Domain-like 1.
SpecificityRecognizes human GTPase Activating Rap/RanGAP Domain-like 1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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