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You are here:Home » Antibodies » Antibodies-Enzymes, Cyclase » Anti -Guanylate Cyclase 1, Soluble, Beta 3 (GUCY1B3, guanylate cyclase soluble, beta-1 chain)

Anti -Guanylate Cyclase 1, Soluble, Beta 3 (GUCY1B3, guanylate cyclase soluble, beta-1


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
Beta1 subunit of guanylate cyclase is a heterodimeric protein consisting of an alpha subunit and a beta subunit linked by disulphide bonds. Guanylate cyclase functions as the main receptor for nitric oxide, whereupon it catalyzes the conversion of GTP to the second messenger cGMP. cGMP mediates the vasodilator capacity of NO, and is important in modulating other vascular functions, including cellular proliferation, apoptosis, migration and extracellular matrix production. Guanylate cyclase beta1 has recently been shown to be upregulated in mononuclear cells from patients with erectile dysfunction.
Catalog #G9804-50A
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
FormSupplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to aa189-207 from human GUCY1B3 (KLH).
SpecificityRecognizes human GUCY1B3. Species sequence homology: Mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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