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You are here:Home » Antibodies » Abs to Enzymes, Cyclase » Anti -Guanylate Cyclase, Soluble (sGC)

Anti -Guanylate Cyclase, Soluble (sGC)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B
The beta1 subunit of guanylate cyclase is a heterodimeric protein consisting of an alpha subunit and a beta subunit linked by disulfide bonds. Guanylate Cyclase functions as the main receptor for nitric oxide, whereupon it catalyzes the conversion of GTP to the second messenger cGMP. cGMP mediates the vasodilator capacity of NO, and is important in modulating other vascular functions, including cellular proliferation, apoptosis, migration and extracellular matrix production.
Catalog #G9804-56A
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
HybridomaSp2/0 myeloma cells with spleen cells from Balb/c mice.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No9L298
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenRecombinant human soluble Guanylate Cyclase alpha1 beta1 heterodimer.
SpecificityRecognizes the beta1 subunit of guanylate cyclase at ~70kD in human lung cell lysate.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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