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G9951-25 GW2580, Free Base (5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine) CAS: 870483-87-7

Specifications
References
CAS Number
870483-87-7
Grade
Highly Purified
Molecular Formula
C20H22N4O3
Molecular Weight
366.41
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine)

GW2580 is a small-molecule inhibitor of cFMS kinase; at 60nM it inhibited human cFMS kinase completely in vitro and was inactive against 26 other kinases. GW2580 inhibited lipopolysaccharide (LPS)-induced TNF production in mice, but not LPS-induced TNF production in freshly isolated human monocytes and mouse macrophages in vitro. Also, GW2580 at 1uM totally inhibited CSF-1-induced growth of mouse M-NFS-60 myeloid cells and human monocytes, and prevented bone degradation in cultures of rat calvaria and rat fetal long bone in vitro.

Synonyms
(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine)
CAS No
870483-87-7
Molecular Formula
C20H22N4O3
Molecular Weight
366.41
Appearance
White to off-white powder
Purity
≥99%
Melting Point
209-210.5°C
Elemental Analysis
Calculated: C65.56%, H6.05%, N15.29% Found: C~65%, H~6%, N~15%
Solubility
Soluble in DMSO at 40mg/ml; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 20-100uM; buffers, serum, or other additives may increase or decrease the aqueous solubility.
Storage and Stability
Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
References
1. Conway, J.G., et al., Proc. Natl. Acad. Sci. USA 102: 16,078-16,083 (2005). 2. Conway, J.G., et al., J. Pharmacol. Exp. Ther. 326: 41-50 (2008).
USBio References
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