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You are here:Home » Molecular Biology » MB-Enzymes, Dehydrogenase » HADH2, aa12-261, Recombinant, Human (Hydroxyacyl-Coenzyme A Dehydrogenase Type II, Type II HADH, AB-binding Alcohol Dehydrogenase, ABAD, CAMR, DUPXp11.22, ERAB, HCD2, HSD17B10, MHBD, Mitochondrial Ribonuclease P Protein 2, MRPP2, MRX17, MRX31, MRXS10, SCH

HADH2, aa12-261, Recombinant, Human (Hydroxyacyl-Coenzyme A Dehydrogenase Type II, Type II
HADH, AB-binding Alcohol Dehydrogenase, ABAD, CAMR, DUPXp11.22, ERAB, HCD2, HSD17B10,
MHBD, Mitochondrial Ribonuclease P Protein 2, MRPP2, MRX17, MRX31, MRXS10, SCH

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Specifications

HSD17B10 is a member of the short-chain dehydrogenase/reductase superfamily. This mitochondrial protein catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids. HSD17B10 plays an important role in processing steroid hormones and fats, and also helps break down the protein building block (amino acid) isoleucine. This enzyme is also necessary for several chemical reactions involving female sex hormones (estrogens) and male sex hormones (androgens). It is essential for maintaining appropriate levels of male and female sex hormones. This protein may contribute to the neuronal dysfunction associated with Alzheimer disease. Recombinant HSD17B10 protein was expressed in E. coli.
Catalog #H1500-03
SourceRecombinant corresponding to aa12-261 of human HSD17B10 6x His tagged expressed in E. coli.
AA SequenceMGSSHHHHHH SSGLVPRGSH MVAVITGGAS GLGLATAERL VGQGASAVLL DLPNSGGEAQ AKKLGNNCVF APADVTSEKD VQTALALAKG KFGRVDVAVN CAGIAVASKT YNLKKGQTHT LEDFQRVLDV NLMGTFNVIR LVAGEMGQNE PDQGGQRGVI INTASVAAFE GQVGQAAYSA SKGGIVGMTL PIARDLAPIG IRVMTIAPGL FGTPLLTSLP EKVCNFLASQ VPFPSRLGDP AEYAHLVQAI IENPFLNGEV IRLDGAIRMQ P
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight28.1kD
SourceE. coli
Purity~ 95% (SDS-PAGE). Purified by using conventional chromatography techniques.
ConcentrationAs reported
FormSupplied as a liquid in 20mM Tris HCl, pH 8.0, 1mM DTT, 100mM NaCl, 10% glycerol.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate names3-hydroxyacyl-CoA Dehydrogenase Type 2, 3-hydroxyacyl-CoA Dehydrogenase Type II, 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase, 17beta-hydroxysteroid Dehydrogenase 10, EC=1.1.1.35, EC=1.1.1.178, Endoplasmic Reticulum-associated Amyloid beta Peptide Binding


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