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You are here:Home » Antibodies » Antibodies-Disease Markers » Anti -Hamartin (TSC1, Tuberous Sclerosis 1) (Isoform 1)

Anti -Hamartin (TSC1, Tuberous Sclerosis 1) (Isoform 1)


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Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
This gene encodes a growth inhibitory protein thought to play a role in the stabilization of tuberin. Mutations in this gene have been associated with tuberous sclerosis. Alternative splicing results in multiple transcript variants.
Catalog #H1779-02D
ApplicationsSuitable for use in ELISA and Western Blot. Other applications have not been tested.
Recommended Dilutions
Peptide ELISA Titer: 1:128,000
Western Blot: 0.1-0.3ug/ml detects ~150kD band observed in Human Brain lysates (calculated MW of 130kD according to NP_000359.1). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Miloloza et al Hum Mol Genet. 2000 Jul 22;9(12):1721-7; PMID: 10915759). In transfected HEK293 transiently expressing Human TSC1 a band of approx. 120kD is observed. This band is not observed in the non-transfected HEK293.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
FormSupplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
PurityPurified by peptide affinity chromatography.
ImmunogenSynthetic peptide corresponding to C-QLHIMDYNETHHEH, from the C Terminus of human Hamartin (NP_000359.1).
SpecificityRecognizes human Hamartin. This antibody is expected to recognise tuberous sclerosis isoform 1 (NP_000359.1) only. Species sequence homology: mouse, rat, canine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namestumor suppressor, tuberous sclerosis 1 protein, TSC, MGC86987, LAM, KIAA0243, HGNC:12362, tuberous sclerosis 1, hamartin, TSC1

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