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You are here:Home » Antibodies » Abs to Disease Markers » Anti -Huntingtin-Associated Protein 1 (Neuroan 1, HLP, HIP5)

Anti -Huntingtin-Associated Protein 1 (Neuroan 1, HLP, HIP5)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin (reviewed in 1). HAP1 was initially identified through a two-hybrid library screening; the binding of HAP1 to huntingtin correlated with the expansion of the polyglutamine tract (2). HAP1 also interacts with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), suggesting that HAP1 may play a role in vesicular trafficking or organelle transport (3). HAP1 is also involved with the huntingtin-enhanced BDNF transport along the cellular microtubles. Attenuation of this process led to the loss of neurotrophic support and neuronal toxicity, which suggests that loss of this function might contribute to pathogenesis (4). Several alternatively spliced isoforms have been described for HAP1.
Catalog #H1815-07
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-1 ug/ml.
Optimal dilutions to be determined by the researcher.
Positive ControlA-20 cell lysate
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
Immunogen19 amino acid peptide from near the center of human HAP1
(GenBank accession no. CAC09418).
SpecificityRecognizes human HAP1. Species Crossreactivity: Mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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