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H1815-07A Rabbit Anti-Huntingtin-Associated Protein 1 (HAP-1, Neuroan 1, HLP, HIP5) (Not for Export EU)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Rat
Isotype
IgG
Grade
Serum
Applications
IHC
Crossreactivity
Rt
Shipping Temp
Blue Ice
Storage Temp
-20°C
HAP1

Associates specifically with huntingtin. This binding is enhanced by an expanded polyglutamine repeat.

Alternative Products
2 named isoforms produced by alternative splicing.
Tissue Specificity
In the brain, especially in the olfactory bulb and in the brain stem. No detectable expression in peripheral tissues such as lung, testis, spleen, and small intestine. Contains 1 HAP1 N-terminal domain.
Applications
Suitable for use in Immunohistochemistry. Other applications not tested.
Recommended Dilution
Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Immunogen
Recombinant rat HAP-1.
Form
Supplied as a lyophilized powder. Reconstitute in 100ul of sterile water. Centrifuge to remove any insoluble material.
Purity
Serum
Specificity
Specificity for HAP-1 was confirmed by IHC. Species Crossreactivity: This antiserum is known to react with rat HAP-1. Other species have not yet been tested.
References
1. Zhou, H. et al. (2003). J. Cell Biol. 163(1): 109-118. ; 2. Fusco, F.R. et al. (2003). Eur. J. Neurosci. 18: 1-10. ; 3. Pardo, R. et al. (2006). J. Neurosci. 26(5): 1635-1645. ; 4. Harper, S. Q. et al. (2005). Proc. Nat. Acad. Sci. (USA) 102: 5820-5825. ; 5. Qin, Z. et al. (2004). J. Neurosci. 24(1): 269-281. ; 6. Tang, T. S. et al. (2003). Neuron 39(2): 227-239.
USBio References
No references available
Conjugates
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