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You are here:Home » Antibodies » Abs to Disease Markers » Anti -HAP1 (Huntingtin-associated Protein 1, HAP-1, Neuroan 1, HAP2, HLP1)

Anti -HAP1 (Huntingtin-associated Protein 1, HAP-1, Neuroan 1, HAP2, HLP1)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified B
Huntington's disease (HD) is caused by the expansion of a glutamine repeat in the protein huntington. The expanded glutamine repeat is thought to mediate a gain of function by causing huntingtin to abnormally interact with other proteins. As vitro binding, immunoprecipitation, and co-expression studies have shown, the huntingtin-associated protein 1 (HAP1) physically interacts with huntingtin. Human HAP1 is a 75kD protein which is specifically expressed in human brain and binds more tightly to mutant huntingtin with an expanded glutamine repeat than to wild type huntingtin. Human HAP1 shares 62% identity with rat HAP1 over its entire sequence and 82%aa identity in the putative huntingtin-binding region. Its expression in Huntington's disease brains is reduced in parallel with a decreased expression of huntingtin.
Catalog #H1815-07D
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.1-0.3ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHuman brain (Frontal Cortex and Hippocampus) lysates
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-RYDFRYSEDREQ, from the internal region of the protein sequence according to NP_817084; NP_001073340.
SpecificityRecognizes human HAP1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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