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Anti -HAP1 (Huntingtin-associated Protein 1, HAP-1, Neuroan 1, HAP2, HLP1)
Anti -HAP1 (Huntingtin-associated Protein 1, HAP-1, Neuroan 1, HAP2, HLP1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E |
|
| Huntington's disease (HD) is caused by the expansion of a glutamine repeat in the protein huntington. The expanded glutamine repeat is thought to mediate a gain of function by causing huntingtin to abnormally interact with other proteins. As vitro binding, immunoprecipitation, and co-expression studies have shown, the huntingtin-associated protein 1 (HAP1) physically interacts with huntingtin. Human HAP1 is a 75kD protein which is specifically expressed in human brain and binds more tightly to mutant huntingtin with an expanded glutamine repeat than to wild type huntingtin. Human HAP1 shares 62% identity with rat HAP1 over its entire sequence and 82%aa identity in the putative huntingtin-binding region. Its expression in Huntington's disease brains is reduced in parallel with a decreased expression of huntingtin. | | | Catalog # | H1815-07F | | Applications | Suitable for use in ELISA. Other applications not tested. | | Recommended Dilution | ELISA: 1:32,000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, 0.02% sodium azide. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Synthetic peptide corresponding to aa639-653 [YRRQLRWKMLQKGEC] of the human huntingtin-associated protein 1. | | Specificity | Recognizes HAP1. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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