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You are here:Home » Antibodies » Abs to Ion Channel » Anti -HCN1 (Hyperpolarization-activated Cyclic Nucleotide-gated channel 1)

Anti -HCN1 (Hyperpolarization-activated Cyclic Nucleotide-gated channel 1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Biological rhythms (beating of the heart, circadian sleep cycles, respiration, and the release of hormones) are necessary to sustain life. Heart beating is the most reliable and rhythmic biological phenomenon. Cardiac pacemaking is produced by the slow diastolic depolarization phase of the action potential. The hyperpolarization- activated cation current (termed If, Ih, or Iq) plays a key role in the in the initiation and modulation of cardiac and neuronal pacemaker depolarization. The generation of cardiac pacemaker potentials relies on a complex interplay between at least four different types of cation channels: T- and L-type Ca2+ channels, K+ channels, and a cation channel termed If (synonymous names are Ih and Iq). The If channel has been designated as "pacemaker" channel because it reveals unique features that are believed to be a prerequisite for pacemaker activity. Recently, the hyperpolarization-activated cyclic nucleotide-gated families of ion channel proteins (HCN1-4) have been identified as the "pacemaker" channel. The amino acid sequences of HCNs predict a structure similar to that of voltage-gated (Kv) channels and cyclic nucleotide-gated (CNG) channels.
Catalog #H1827-25F
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1-10ug/ml using ECL.
ELISA: 1:10,000-1:100,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.1% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenA 14aa peptide sequence, mapping near the cytoplasmic, N-terminus of human/mouse HCN1 (Accession #NP_034538). Conjugated to KLH. Species Sequence Homology: mouse-100%, rabbit and rat -92%.
SpecificityRecognizes human HCN1. No reactivity is observed with other HCN proteins.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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