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You are here:Home » Antibodies » Abs to Ion Channel » Anti -HCN4 (Hyperpolarization-activated Cyclic Nucleotide-gated channel 4)

Anti -HCN4 (Hyperpolarization-activated Cyclic Nucleotide-gated channel 4)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E B
Biological rhythms (beating of the heart, circadian sleep cycles, respiration, and the release of hormones) are necessary to sustain life. Heart beating is the most reliable and rhythmic biological phenomenon. Cardiac pacemaking is produced by the slow diastolic depolarization phase of the action potential. The hyperpolarization-activated cation current (termed If, Ih, or Iq) plays a key role in the in the initiation and modulation of cardiac and neuronal pacemaker depolarization. The generation of cardiac pacemaker potentials relies on a complex interplay between at least four different types of cation channels: T- and L-type Ca2+ channels, K+ channels, and a cation channel termed If (synonymous names are Ih and Iq). The If channel has been designated as "pacemaker" channel because it reveals unique features that are believed to be a prerequisite for pacemaker activity. Recently, the hyperpolarization-activated cyclic nucleotide-gated families of ion channel proteins (HCN1-4) have been identified as the "pacemaker" channel.
Catalog #H1827-30D
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000-1:5000.
ELISA: 1:10,000-1:100,000 using 50-100ng of control peptide/well.
Optimal dilutions to be determined by the researcher.
Control PeptideH1827-30H HCN4, Rat Control Peptide
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceRat
ConcentrationNot determined
FormSupplied as a liquid in PBS, 0.05% sodium azide, 40% glycerol.
PuritySerum
ImmunogenA 15-aa peptide sequence corresponding to the cytoplasmic, C-terminus of rat HCN4 (KLH).
SpecificityRecognizes rat Hyperpolarization-activated Cyclic Nucleotide-gated channel 4. Species sequence homology: (93%) rabbit and (86%) human, primate. No significant sequence homology is seen with other HCNs or any other protein.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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