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You are here:Home » Antibodies » Abs to Enzymes, Deacetylase » Anti -HDAC8 (Histone Deacetylase 8, HD8, CDA07, HDAC8, HDACL1)

Anti -HDAC8 (Histone Deacetylase 8, HD8, CDA07, HDAC8, HDACL1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
HDAC8 is a 377 residue class I enzyme that lies close to the phylogenetic boundary between the class I and class II histone deacetylases and maps to the X chromosome (Xq13). HDAC8, under the regulation of PKA, plays an important role in determining the acetylation state of histones. HDAC8 is phosphorylated by cyclic AMP-dependent protein kinase A (PKA) which decreases the activity of HDAC8 and leads to the hyperacetylation of histones H3 and H4. Pathological role of HDAC8 has been observed in one of the most frequent types of acute myeloid leukemia (AML).
Catalog #H1827-56F7
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000
Immunohistochemistry (paraffin): 1:50-1:100
Optimal dilutions to be determined by the researcher.
Positive ControlNIH/3T3 cells
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic non-phosphopeptide corresponding to human HDAC8 around the phosphorylation site of serine 39 (R-A-SP-M-V).
SpecificityRecognizes human HDAC8.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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