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You are here:Home » Antibodies » Abs to Enzymes, Deacetylase » Anti -HDAC9 (Histone Deacetylase 9, HD9, Histone Deacetylase 7B, HD7, HD7b, Histone Deacetylase-related Protein, MEF2-interacting Transcription Repressor MITR, HDAC7, HDAC7B, HDRP, KIAA0744, MITR)

Anti -HDAC9 (Histone Deacetylase 9, HD9, Histone Deacetylase 7B, HD7, HD7b, Histone
Deacetylase-related Protein, MEF2-interacting Transcription Repressor MITR, HDAC7, HDAC7B,
HDRP, KIAA0744, MITR)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
HDAC-9 is a histone deacetylase with an important role in the regulation of gene expression and hematopoiesis. A nuclear protein, HDAC-9 belongs to the histone deacetylase family with several isoforms and is inhibited by Trichostatin A (TSA) and suberoylanilide hydroxamic acid. It helps in deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) and gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. MEF2-dependent transcription is repressed by HDAC-9 by recruiting HDAC-1 and/or HDAC-3. It also inhibits skeletal myogenesis and is involved in heart development. Ubiquitous but variable expression is seen in brain and other tissues like heart, pancreas and also in human bladder carcinoma cells. Lack of HDAC-9 protein is found in a family with Peters anomaly, a central corneal leukoma.
Catalog #H1827-56M
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-2ug/ml
Immunohistochemistry (formalin fixed paraffin embedded): 5ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to aa100-150 of human HDAC-9.
SpecificityRecognizes human HDAC9. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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