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You are here:Home » Antibodies » Abs to Enzymes, Deacetylase » Anti -HDAC11 (Histone Deacetylase 11, HD11, HD-11, FLJ22237)

Anti -HDAC11 (Histone Deacetylase 11, HD11, HD-11, FLJ22237)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH
HDAC11 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation is a marker for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. The predominantly nuclear HDAC11, which interacts with HDAC6, is weakly expressed in most tissues, and strongly expressed in brain, heart, skeletal muscle, kidney and testis. Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.
Catalog #H1827-57E
ApplicationsSuitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested.
Recommended DilutionELISA: 1:1000
Western Blot: 1:25
Immunohistochemistry: 1:50-1:100
Optimal dilutions to be determined by the researcher.
Positive ControlMouse Brain cell lysate
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~0.25mg/ml
FormSupplied as a liquid, 0.09% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic peptide corresponding the N-terminal region of human HDAC11 (KLH).
SpecificityRecognizes human HDAC11. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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