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Abs to Heat Shock Proteins
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Anti -Heat Shock Factor 1 (Heat Shock Factor Protein 1, HSF 1, HSF1, Heat Shock Transcription Factor 1, HSTF 1, HSTF1)
Anti -Heat Shock Factor 1 (Heat Shock Factor Protein 1, HSF 1, HSF1, Heat Shock
Transcription Factor 1, HSTF 1, HSTF1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IH |
|
| HSF1 is the major heat shock transcriptional factor that binds heat shock element (HSE) in the promoter of heat shock proteins (Hsps) and controls rapid Hsp induction in cells subjected to various environmental stresses. HSF1 gene belongs to a family of vertebrate HSF transactivators, and encodes the orthologous protein found across the eukaryotic phyla. HSF1 regulates HSP synthesis and activates hsp gene transcription. Under normal conditions, cellular HSF1 exists in a transcriptionally repressed state. Induction of transcriptional activity by heat shock then results in the conversion of HSF1 from inactive monomer to a DNA-binding trimer. human HSF1 gene is localized on chromosome 8q24.3. | | | Catalog # | H1830-44L | | Applications | Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1:500-1:1000 | | Immunohistochemistry (paraffin): 1:50-1:100 | | Optimal dilutions to be determined by the researcher. | | Positive Control | MCF7 cells | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic non-phosphopeptide corresponding to human HSF1 around the phosphorylation site of serine 303 (P-P-SP-P-P). | | Specificity | Recognizes human HSF1. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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