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You are here:Home » Antibodies » Abs to Heat Shock Proteins » Anti -Heat Shock Factor 1 (Heat Shock Factor Protein 1, HSF 1, HSF1, Heat Shock Transcription Factor 1, HSTF 1, HSTF1)

Anti -Heat Shock Factor 1 (Heat Shock Factor Protein 1, HSF 1, HSF1, Heat Shock
Transcription Factor 1, HSTF 1, HSTF1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
HSF1 is the major heat shock transcriptional factor that binds heat shock element (HSE) in the promoter of heat shock proteins (Hsps) and controls rapid Hsp induction in cells subjected to various environmental stresses. HSF1 gene belongs to a family of vertebrate HSF transactivators, and encodes the orthologous protein found across the eukaryotic phyla. HSF1 regulates HSP synthesis and activates hsp gene transcription. Under normal conditions, cellular HSF1 exists in a transcriptionally repressed state. Induction of transcriptional activity by heat shock then results in the conversion of HSF1 from inactive monomer to a DNA-binding trimer. human HSF1 gene is localized on chromosome 8q24.3.
Catalog #H1830-44L
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000
Immunohistochemistry (paraffin): 1:50-1:100
Optimal dilutions to be determined by the researcher.
Positive ControlMCF7 cells
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic non-phosphopeptide corresponding to human HSF1 around the phosphorylation site of serine 303 (P-P-SP-P-P).
SpecificityRecognizes human HSF1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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