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You are here:Home » Antibodies » Abs to Heat Shock Proteins » Anti -Heat Shock Protein 22 (HSPB8, HSP22, CRYAC)

Anti -Heat Shock Protein 22 (HSPB8, HSP22, CRYAC)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B
Heat shock protein beta-8 (HSPB8, also HSP22 or CRYAC) is a 22-25kD member of the small HSP (HSP20) family of proteins. It is expressed in muscle (smooth, skeletal and cardiac), and serves as a molecular chaperone. Human HSPB8 contains one -crystalline domain (aa 93-170) that mediates protein-protein interaction, and N- plus C-terminal flanking sequences that generate homodimers, homooligomers, and heterodimers with HSP27 and HSPB7. Phosphorylation at Ser57 blocks HSPB8 chaperone activity. Human HSPB8 shares 94% aa identity with both mouse and canine HSPB8. Deficiencies in HSPB8 are involved in distal motor neuropathy type 11A.
Catalog #H1830-48K
ApplicationsSuitable for use in Western Blot. other applications not tested.
Recommended DilutionWestern Blot: 0.5ug/ml.
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute by adding sterile buffer. Aliquot and store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No10F616
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a lyophilized powder in PBS, 5% trehalose. Reconstitute in 100ul of PBS, 0.02% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenE. coli-derived recombinant human HSPB8 (aa1-196)
Accession# Q9UJY1).
SpecificityRecognizes endogenous human HSPB8 at 22kD in Western blot. Species Crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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