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Anti -Heat Shock Protein 22 (HSPB8, HSP22, CRYAC)
Anti -Heat Shock Protein 22 (HSPB8, HSP22, CRYAC)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
B |
|
| Heat shock protein beta-8 (HSPB8, also HSP22 or CRYAC) is a 22-25kD member of the small HSP (HSP20) family of proteins. It is expressed in muscle (smooth, skeletal and cardiac), and serves as a molecular chaperone. Human HSPB8 contains one -crystalline domain (aa 93-170) that mediates protein-protein interaction, and N- plus C-terminal flanking sequences that generate homodimers, homooligomers, and heterodimers with HSP27 and HSPB7. Phosphorylation at Ser57 blocks HSPB8 chaperone activity. Human HSPB8 shares 94% aa identity with both mouse and canine HSPB8. Deficiencies in HSPB8 are involved in distal motor neuropathy type 11A. | | | Catalog # | H1830-48K | | Applications | Suitable for use in Western Blot. other applications not tested. | | Recommended Dilution | Western Blot: 0.5ug/ml. | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute by adding sterile buffer. Aliquot and store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 10F616 | | Host | Mouse | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a lyophilized powder in PBS, 5% trehalose. Reconstitute in 100ul of PBS, 0.02% sodium azide. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | E. coli-derived recombinant human HSPB8 (aa1-196) | | Accession# Q9UJY1). | | Specificity | Recognizes endogenous human HSPB8 at 22kD in Western blot. Species Crossreactivity: mouse and rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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