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You are here:Home » Antibodies » Abs to Heat Shock Proteins » Anti -Heat Shock Protein 40 (Heat Shock 40kD Protein 1, HSP40, DnaJ Homolog Subfamily B Member 1, DNAJB1, DnaJ Protein Homolog 1, DNAJ1, HSPF1, Human DnaJ Protein 1, HDJ1, hDj-1, RSPH16B, Sis1)

Anti -Heat Shock Protein 40 (Heat Shock 40kD Protein 1, HSP40, DnaJ Homolog Subfamily B
Member 1, DNAJB1, DnaJ Protein Homolog 1, DNAJ1, HSPF1, Human DnaJ Protein 1, HDJ1, hDj-1,
RSPH16B, Sis1)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IP
Human Hsp40/DnaJ proteins comprise a large protein family, members of which feature the J domain (named after the bacterial DnaJ protein) (1). The J-domain spans the first 75 N-terminal amino acids and is separated from the C-terminal by a glycine/phenylalanine-rich domain (2). There are two main types of Hsp40; type 1 DNAJ proteins including HDJ2 and yeast YdjI; type II includes yeast Sis1 and human Hdj1. Whereas type I possesses a zinc finger domain which helps in the function of protein folding. (3, 4), type II does not. Members of the Hsp40/DnaJ family play diverse roles in many cellular processes, such as folding, translocation,
degradation and assembly of multi-protein complexes. Hsp40 stimulates the ATPase activity of Hsp70 which in turn causes conformational changes of the unfolded proteins (5, 6). The Hsp40-Hsp70-unfolded protein complex further binds to co-chaperones Hip, Hop and HSP90 which leads to protein folding, or components of protein degradation machinery CHIP and BAG-1 (7).
Catalog #H1830-64D
ApplicationsSuitable for use in ELISA, Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionWestern Blot:1:2000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1/Kappa
Clone No10F715
HostMouse
Concentration~1mg/ml
FormSupplied as a liquid in 0.09% sodium azide in 50% glycerol.
PurityPurified by Protein G affinity chromatography.
ImmunogenFull length protein HSP40 (YDJ1).
SpecificityRecognizes hsp40. Species Crossreactivity: Yeast, does not cross react with human, rat
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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