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You are here:Home » Antibodies » Abs to Heat Shock Proteins » Anti -Heat Shock Cognate Protein 70 (HSC70, HSP73) (Biotin)

Anti -Heat Shock Cognate Protein 70 (HSC70, HSP73) (Biotin)

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Specifications

Clone Host Grade Applications
Monoclonal Rat Affinity Purified E B IP IH IC FC
The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.
Catalog #H1831-25F
ApplicationsSuitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry, Immunoprecipitation, FACS and Immunoelectron Microscopy. Other applications not tested.
Recommended DilutionsWestern Blot: 1:1000 (ECL)
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No6i2
HostRat
SourceHamster
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Labeled with Biotin.
PurityPurified by Protein G affinity chromatography.
ImmunogenNative hamster Hsc70
SpecificityRecognizes hamster Hsc70 at ~73kD.
Species CrossreactivityHuman, mouse, rat, bovine, canine, chicken, guinea pig, monkey, porcine, rabbit and sheep
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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