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You are here:Home » Antibodies » Abs to Heat Shock Proteins » Anti -Heat Shock Cognate Protein 70 (HSC70, HSP73)

Anti -Heat Shock Cognate Protein 70 (HSC70, HSP73)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse B IP IH
The HSP 70 family is a set of highly conserved proteins that are induced by a variety of biological stresses, including heat stress, in every organism in which the proteins have been examined. The human HSP 70 family members include: HSP 70, a protein which is strongly inducible in all organisms but which is also constitutively expressed in primate cells; HSP 72, a 72kD protein that is induced exclusively under stress conditions; Hsc 70, or cognate protein, is a 72kD, constitutively expressed, protein which is involved in the uncoating of clathrin coated vesicles; GRP 78, or BiP, is a glucose regulated 78kD protein localized in the endoplasmic reticulum; and p75, or Hsc 75, a 75kD protein that is found within the mitochondria. Hsc 70 (also known as Hsc 71, Hsc 73, Hsc 73, p72, prp 73) is expressed constitutively and is slightly heat-inducible. Hsc 70 binds to the exposed loop of clathrin light chains to promote uncoating and can also bind the cytoskeleton which may facilitate cytoskeletal rearrangements. Hsc 70 has been shown to stimulate lysosomal degradation of intracellular proteins and to retard both aggregation and folding of mitochondrial precursor proteins in vitro.
Catalog #H1831-25J
ApplicationsSuitable for use in Western Blo, Immunoprecipitation and Immunohistochemistry (Fr). Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgM
Clone No8L134
HostMouse
SourceMouse
ConcentrationNot determined
FormSupplied as a liquid in PBS, pH 7.2.
PurityAscites
ImmunogenMouse spermatogenic cell protein.
SpecificityThis antibody displays slight crossreactivity to HSP 70. Species Crossreactivity: Crossreacts with Human and Mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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