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You are here:Home » Antibodies » Antibodies-Heat Shock Proteins » Anti -Heat Shock Cognate Protein 70 (HSC70, HSP73)

Anti -Heat Shock Cognate Protein 70 (HSC70, HSP73)


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Clone Host Grade Applications
Monoclonal Mouse Ascites B IP IH
HSC70-interacting protein (Hip) is a cytosolic protein that exists as a homo-oligomer and participates in the regulation of the heat shock protein HSC70 in eukaryotic cells. Hip interacts with the ATPase domain of HSC70 molecules through the tetratricopeptide repeats and flanking charged a-helices of Hip. This binding reaction is dependent on HSP40 in the presence of ATP and becomes Hsp40-independent if HSC70 is preincubated with ADP. Upon binding to HsSC70, Hip stabilizes the ADP-bound state of HsSC70, a conformation that has a high affinity for unfolded substrate proteins. Hip by itself binds unfolded polypeptides, suggesting that it may possess chaperone activity. Together with HSP40, Hip may regulate the chaperone activity of HSC70 by stabilizing the chaperone- substrate complex.
Catalog #H1831-25M
ApplicationsSuitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:2500
Immunohistochemistry: 1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
Clone No6D447
ConcentrationNot determined
FormSupplied as a liquid in PBS, 0.05% sodium azide before addition of glycerol to 40%.
ImmunogenMouse spermatogenic cell protein.
SpecificityRecognizes mouse HSC70 (heat shock cognate protein 70) at ~70kD by Western Blot. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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