Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Antibodies » Abs to Heat Shock Proteins » Anti -Heat Shock Cognate Protein 70 (HSC70, Constitutive Heat Shock Protein 70, Heat Shock 70kD Protein 10, Heat Shock 70kD Protein 8, Heat Shock 70kDa Protein 8, Heat Shock Cognate 71kD Protein, Heat Shock Cognate Protein 54, HSC54, Heat Shock Cognate Protein

Anti -Heat Shock Cognate Protein 70 (HSC70, Constitutive Heat Shock Protein 70, Heat Shock
70kD Protein 10, Heat Shock 70kD Protein 8, Heat Shock 70kDa Protein 8, Heat Shock Cognate
71kD Protein, Heat Shock Cognate Protein 54, HSC54, Heat Shock Cognate Protein

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant E B IP IH IC FC
Hsp73 is a normal cell constituent which is synthesized in increased abundance under adverse environmental circumstances, such as non-physiological temperatures or treatment with amino acid analogues (1). Data has shown a molecular mechanism for cytokine-mediated posttranscriptional regulation of Bim mRNA by Hsc70, which binds to AU-rich elements (AREs) in the 3'-untranslated region of specific mRNAs and enhances their stability. The RNA binding potential of Hsc70 is regulated by cochaperones including Bag-4 (also SODD), CHIP, Hip, and Hsp40 (2). Hsp73 protein expression was detected in the cytoplasm of melanoma cells in primary tumors and metastases. In primary melanomas, the proportion of Hsp73 protein expressing cells correlated with tumor thickness which was found to be statistically significant.
Catalog #H1831-25N
ApplicationsSuitable for use in Flow Cytometry, ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. Other applications not tested.
Recommended DilutionFlow Cytometry: 1:30
Western Blot: 1:500
Immunoprecipitation: 1:10
Immunohistochemistry: 1:250-1:500
Immunocytochemistry: 1:100-1:250
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
IsotypeIgG
Clone No9H359
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
PuritySupernatant.
ImmunogenSynthetic peptide corresponding to residues near the C-terminus of human Hsp73.
SpecificityRecognizes human Hsp73. Species Crossreactivity: Mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


External Links