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You are here:Home » Antibodies » Abs to Heat Shock Proteins » Anti -Heat Shock Protein 110 (HSP110)

Anti -Heat Shock Protein 110 (HSP110)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP
Hsp 110 (110kD) belongs to a family of large stress proteins referred to as the Hsp110/SSE family (1). The proteins in this family are the most distantly known relatives of the well studied Hsp70 family. Members of this group are significantly larger in size and contain sequences not present in members of the Hsp70 family. The mammalian protein has recently been cloned (1) and found to share 3033% amino acid identity with members of the Hsp70 family, most of which occurs in the conserved ATP-binding domain of these molecules. Presently, all identified members of the Hsp70-like sequences can be categorized as being members of either one of these two groups; i.e. the DnaK (i.e. Hsp70) family or the Hsp110/SSE family (1). While most stress protein families (20kD, 60kD, 70kD, and 90kD) have been studied extensively, the Hsp110 species has been virtually ignored. Reports to date indicate that Hsp110 is a normal constituent of mammalian cells, it is induced by heat shock and its induction strongly correlates with the expression of thermotolerance (2). Furthermore, Hsp110 has been shown to be associated with the nucleolus (3) and Western blot analysis of several murine tissues indicates that Hsp110 is constitutively expressed at varying levels in all mouse tissues and is highly expressed in brain (1).
Catalog #H1833-05
ApplicationsSuitable for use in Immunoprecipitation and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1ug/ml (colorimetric)
Optimal dilution to be determined by researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.09% sodium azide, 50% glycerol.
PurityPurified by Protein A affinity chromatography
ImmunogenSynthetic peptide derived from the sequence of hamster Hsp 110. Sequence identical to human and mouse.
SpecificityRecognizes a ~110kD protein, corresponding to the apparent molecular mass of human Hsp110. Species Crossreactivity: monkey, hamster, rat, mouse, bovine, sheep and yeast cell lines.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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