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Specifications

Clone Host Grade Applications Polyclonal Rabbit Affinity Purified B

Hsp110 belongs to a family of large stress proteins known as the Hsp110/SSE Family. The proteins in this family are the most distantly known relatives of the well studied Hsp70 family. They share 30-33% amino acid identity, mostly in the conserved ATP-binding domain (1).
Hsp110 cooperates with Hsp70 in protein folding in the eukaryotic cytosol (2). In mammals, Hsp110 is constitutively expressed, but exhibits particularly high levels in the brain. Both Hsp70 and Hsp110 are elevated after cerebral ischemia. Recent studies demonstrate that the protective effects of Hsp110 deficiency in cerebral ischemia may partly be mediated by an increase in the chaperone activity of Hsp70 (3). Studies also suggest that Hsp110 can be used in heat shock protein-based cancer immunotherapy (4).
Catalog #	H1833-10B
Applications	Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution	Western Blot:1:1000
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Source	Hamster
Concentration	~1mg/ml
Form	Supplied as a liquid in PBS, pH7.2, 50% glycerol and 0.09% sodium azide.
Purity	Purified by immunoaffinity chromatography.
Immunogen	Synthetic peptide derived from the sequence of hamster Hsp110; sequence identical to human and mouse.
Specificity	Recognizes hamster hsp110. Species Crossreactivity: human, monkey, rat, mouse, bovine, sheep, yeast.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.