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Anti -Heparan Sulfate Proteoglycan (Perlecan, HSPG)
Anti -Heparan Sulfate Proteoglycan (Perlecan, HSPG)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rat |
Affinity Purified |
IH |
|
| Perlecan is a major heparan sulfate proteoglycan (HSPG) found within all basement membranes and cell surfaces. Because of its strategic location and ability to store and protect growth facors, perlecan hs been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth promoting attributes primarily by acting as a coreceptor for basic fibroblast growth factor. Suppression of perlican causes substantial inhibition of neoplastic growth and neovasacularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogaenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment. | | | Catalog # | H1890-90 | | Applications | Suitable for use in Immunohistochemistry and in investigating the distribution and possible functions of heparan sulfate proteoglycans. Other applications not tested. | | Recommended Dilution | Immunohistochemistry: 1:25-1:50 (paraffin section). | | Optimal dilutions to be determined by the researcher. | | Hybridoma | Monoclonal antibody is secreted by a hybridoma obtained by fusion of NS-1 mouse myeloma cells with spleen cells from the rat immunized with heparan sulfate proteoglycans extracted from the Engelbreth-Holm-Swarm mouse tumor. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Clone Type | Monoclonal | | Isotype | IgG2a,k | | Clone No | 8.S.225 (HK-102) | | Host | Rat | | Source | Mouse | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in PBS, pH 7.2, 0.01% sodium azide, 40% glycerol. | | Purity | 99% Purified by Protein G affinity chromatography. | | Immunogen | Heparan sulfate proteoglycan from Engelbreth-Holm-Swarm mouse tumor. | | Specificity | Recognizes specifically the core protein moiety of low density HSPG (Perlecan). | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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