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You are here:Home » Antibodies » Abs to Carbohydrates, Glycoproteins » Anti -Heparan Sulfate Proteoglycan, Domain 4 (Perlecan, HSPG)

Anti -Heparan Sulfate Proteoglycan, Domain 4 (Perlecan, HSPG)

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Specifications

Clone Host Grade Applications
Monoclonal Rat Affinity Purified IH IF
Perlecan is a major heparan sulfate proteoglycan (HSPG) found within all basement membranes and cell surfaces. Because of its strategic location and ability to store and protect growth facors, perlecan hs been stronglyimplicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth promoting attributes primarily by acting as a coreceptor for basic fibroblast growth factor. Suppression of perlican causes substantial inhibition of neoplastic growth and neovasacularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogaenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.
Catalog #H1890-92
ApplicationsSuitable for use in Immunofluorescence and Immunohistochemistry. Not suitable for use in Western Blot. Other applications have not been tested.
Recommended DilutionsImmunohistochemistry (Frozen and acid-alcohol fixed, paraffin embedded sections): 1-2ug/ml for 30 minutes at RT. Staining of acid-alcohol-fixed tissues requires antigen unmasking with 15,000u/ml of bovine testicular hyaluronidase in PBS, pH 7.4 for 30 minutes at 37°C
Optimal dilutions to be determined by the researcher.
Positive ControlTonsil
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a,k
Clone No0.N.325 (A7L6)
HostRat
SourceMouse
Concentration~0.2mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide. Also available without BSA and azide. See H1890-92X.
PurityPurified by Protein G affinity chromatography.
ImmunogenMouse EHS laminin preparation. Cellular Localization: Basement membrane
SpecificityRecognizes mouse Heparan Sulfate Proteoglycan. Does not crossreact with laminin, fibronectin or dermatran sulfate proteoglycan. Species Crossreactivity: human, bovine and porcine
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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