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You are here:Home » Antibodies » Antibodies-Carbohydrates, Glycoproteins » Anti -Heparan Sulfate Proteoglycan (Perlecan, HSPG)

Anti -Heparan Sulfate Proteoglycan (Perlecan, HSPG)


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Clone Host Grade Applications
Monoclonal Rat Affinity Purified B IP IH IC
Heparan sulfate proteoglycans (HSPGs) are found on cell surfaces and in the extracelluar matrix of all mammalian tissues, particularly in the core of the basement membrane. HSPGs found in the brain are dystroglycan, N-syndecan, glypican, and perlecan. The composition of HSPGs differs in the protein core, and is thought to determine the location of HSPG in the cell membrane (syndecan and glypican) and extracellular matrix (perlecan and dystroglycan). The postulated functions of HSPG include cell proliferation, differentiation, adhesion, migration and morphogenesis.
Catalog #H1890-93C
Heparan Sulfate Proteoglycan antibodies, in tissues, react strongly and uniformly with basement membranes. The reactivity is independent of the galactosaminoglycan moieties; therefore, the epitope is not sensitive to heparinase treatment.
Suitable for use in Western Blot, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry: 1:100; Detected HSPG in large cell carcinoma tissue.
Immunocytochemistry: 1:500
Optimal dilutions to be determined by the researcher.
Positive ControlHeLa and A431 cells
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone No10H3
FormSupplied as a liquid in 0.1M Tris-Glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenHeparan Sulfate Proteoglycan from EHS mouse tumor. Epitope: HSPG core protein.
SpecificityRecognizes human Heparan Sulfate Proteoglycan (Perlecan). Recognizes domain IV of the core protein of the large Heparan Sulfate Proteoglycan.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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