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You are here:Home » Antibodies » Abs to Coagulation Factors » Anti -Heparin Cofactor II (HCII)

Anti -Heparin Cofactor II (HCII)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Purified E
Heparin Cofactor II (HCII) is also known as heparin cofactor A and dermatan sulfate cofactor. It is a single chain glycoprotein produced in the liver. It circuates in plasma at a concentration of 50-100ug/ml (0.8-1.5mM). HCII is a member of the Serpin family of proteinase inhibitors. HCII exhibits a relatively narrow specificity and is only know to inhibit the serine proteinases thrombin and chymotrypsin. The inhibitory activity toward thrombin is accelerated up to 1000- fold in the presence of optimal concentrations of heparin. Unlike Antithrombin, thrombin inhibition by HCII is also enhanced by dermatan sulfate. HCII has an apearent molucular weight of 65.6kD. Interaction with thrombin results in a covalent 1:1 enzyme-inhibitor complex of 102.6kD.
Catalog #H1892-51
ApplicationsSuitable for use in ELISA and Immunoelectrophoresis. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~5mg/ml
FormSupplied in 10mM HEPES, pH7.4, 0.15M sodium chloride, 50% glycerol.
PurityPurified by caprylic acid and ammonium sulfate precipitations and solid -phase adsorption to remove unwanted crossreactivity.
ImmunogenHuman Heparin Cofactor-II (HCII) purified from plasma.
SpecificitySpecific for HCII.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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