Anti -Hepatitis A Virus Cellular Receptor 2 (HAVCR2, Kidney Injury Molecule 3, KIM3, T
cell Immunoglobulin and Mucin Domain Containing 3, TIMD3, T cell Immunoglobulin Mucin 3,
TIM3)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
E B |
|
| CD4 (MIM 186940)-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. | | | Catalog # | H1900-34A | | Applications | Suitable for use in ELISA and Western Blot. Other applications have not been tested. | | Recommended Dilutions | | | Peptide ELISA Titer: 1:32,000 | | Western Blot: 0.3-1ug/ml ~35kD band observed in Human Tonsil, Thymus, Lymph Node and Spleen lysates (calculated MW of 33.4kD according to NP_116171.3). In transfected HEK293 transiently expressing HAVCR2 a band of ~35kD is observed. This band is not observed in the non-transfected HEK293. | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Goat | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide. | | Purity | Purified by peptide affinity chromatography. | | Immunogen | Synthetic peptide corresponding to C-KWYSHSKEKIQN, from the internal region of human HAVCR2 (NP_116171.3). | | Specificity | Recognizes human HAVCR2. Species sequence homology: canine. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | kidney injury molecule-3, T cell immunoglobulin mucin-3, T cell immunoglobulin mucin 3, Tim-3, TIMD3, KIM-3, FLJ14428, hepatitis A virus cellular receptor 2, TIM3, HAVCR2 |
External Links
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