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Specifications

Clone Host Grade Applications Monoclonal Mouse Highly Purified E

The E antigen is also known as HBeAg or precore antigen. It is one of two HBV core proteins and is secreted into the serum of infected patients, usually early on in the infection. Positive testing for HBeAg usually indicates active replication of HBV and is associated with in increased risk of hepatocellular carcinoma. HBeAg also elicits T cell tolerance and regulates the immune response to the intracellular nucleocapsid of the virus. This HBeAg-mediated immune regulation may predispose to chronicity during perinatal infections and prevent severe liver injury during adult infections.
Catalog #	H1915-09
Applications	Suitable for use in ELISA. Other applications not tested.
Recommended Dilutions	Optimal dilutions to be determined by the researcher.
Recommended Pair	Suitable for use as the capture or solid phase antibody.
	Matched to H1915-08 as the detection or conjugate (label) antibody.
Affinity Constant	1x10e9L/mole
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG2a
Clone No	1.B.309
Host	Mouse
Concentration	~5mg/ml
Form	Supplied as a liquid in PBS, pH 7.2 0.025% sodium azide.
Purity	Purified by DEAE chromatography. ( 90% on SPE gel)
Immunogen	Recombinant HBeAg
Specificity	Recognizes and is specific for the “e” antigen of hepatitis B virus.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.