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Anti -Hepatitis C Virus Core Antigen (HCV) (Biotin)
Anti -Hepatitis C Virus Core Antigen (HCV) (Biotin)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E IH |
|
| Hepatitis C virus (HCV) represents the major etiologic agent of non-A, non-B hepatitis. The pathological changes in hepatitis C are characterized by the histologic triad of lymphoid aggregates in portal tracts, epithelial damage of small bile ducts and micro-and macro-vesicular steatosis. HCV antigens are visible in the cytoplasm of infected hepatocytes by immunohistochemical staining with mono-or polyclonal antibodies. These studies are important to determine the viral load and expression pattern of HCV in the infected liver. The mechanism of hepatocyte and bile duct injury in HCV infection appears to be related to the host immune response to the virus. Direct viral cytopathogenicity may also play a role. | | | Catalog # | H1920-09 | | Applications | Suitable for use in ELISA and Immunohistochemistry. Other applications not tested. | | Recommended Dilutions | Immunohistochemistry: Frozen sections | | Optimal dilutions to be determined by the researcher. | | Positive Control | H1920-04: Hepatitis C Virus Core, 22kD, aa2-192, Recombinant (HCV) | | Source | Cell culture | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2a | | Clone No | 1.B.345 | | Host | Mouse | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.2, 0.01% sodium azide. Labeled with Biotin. | | Purity | Purified by Protein A affinity chromatography. | | Immunogen | Recombinant protein. Epitope: aa1-80 of HCV core antigen. | | Specificity | Recognizes HCV core antigen of live virus, lysates and recombinant antigen. Reactive with genotypes 1a, 1b, 2a and 2b. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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