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You are here:Home » Antibodies » Antibodies-Infectious Disease Hepatitis » Anti -Hepatitis C Virus Core Antigen (HCV) (Biotin)

Anti -Hepatitis C Virus Core Antigen (HCV) (Biotin)


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E IH
Hepatitis C virus (HCV) represents the major etiologic agent of non-A, non-B hepatitis. The pathological changes in hepatitis C are characterized by the histologic triad of lymphoid aggregates in portal tracts, epithelial damage of small bile ducts and micro-and macro-vesicular steatosis. HCV antigens are visible in the cytoplasm of infected hepatocytes by immunohistochemical staining with mono-or polyclonal antibodies. These studies are important to determine the viral load and expression pattern of HCV in the infected liver. The mechanism of hepatocyte and bile duct injury in HCV infection appears to be related to the host immune response to the virus. Direct viral cytopathogenicity may also play a role.
Catalog #H1920-09
ApplicationsSuitable for use in ELISA and Immunohistochemistry. Other applications not tested.
Recommended DilutionsImmunohistochemistry: Frozen sections
Optimal dilutions to be determined by the researcher.
Positive ControlH1920-04: Hepatitis C Virus Core, 22kD, aa2-192, Recombinant (HCV)
Source Cell culture
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone No1.B.345
FormSupplied as a liquid in PBS, pH 7.2, 0.01% sodium azide. Labeled with Biotin.
PurityPurified by Protein A affinity chromatography.
ImmunogenRecombinant protein.
SpecificityRecognizes HCV core antigen of live virus, lysates and recombinant antigen. Reactive with genotypes 1a, 1b, 2a and 2b. Epitope: aa1-80 of HCV core antigen.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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