Hepatocyte Growth Factor beta Chain, Recombinant, Human, Western Blot Control (Hepatocyte
Growth Factor, Hepatopoeitin-A, Scatter Factor, SF, HGF, HPTA)
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| Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase-signalling cascade. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69kD alpha-chain and 34kD beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. | | | Catalog # | H2005-04A | | Source | Recombinant corresponding to aa495-728 from human mature Hepatocyte Growth Factor beta Chain, fused to 6x His-tag at N-terminal, expressed in E. coli. | | Applications | Suitable for use in Western Blot as a control. Other applications not tested. | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Source | E. coli | | Purity | Purified (SDS-PAGE) | | Concentration | As reported | | Form | Supplied as a liquid in 25mM Tris-HCl, pH6.8, 50mM DTT, 1% SDS, 0.1% Bromophenol Blue, 2.5% glycerol. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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