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You are here:Home » Biochemicals » Biochem-Antibiotics » Herbimycin A (Herbimycin, Antibiotic TAN 420F)

Herbimycin A (Herbimycin, Antibiotic TAN 420F)

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Specifications

Herbimycin A is the major analogue of a complex of benzoquinone ansamycin antibiotics isolated from a Streptomyces hygroscopicus. Herbimycin A inhibits the 90-kD heat-shock protein (Hsp90) which provides essential chaperone support to various signal transduction molecules, including including certain steroid hormone receptors and select kinases. Herbimycin has also been shown to inhibit protein tyrosine kinase and angiogensis.
Catalog #H2030-35A
SolubilitySoluble in ethanol, methanol, DMF or DMSO.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with ethanol, methanol, DMF or DMSO.. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related to Antibiotic TAN 420C, Antibiotic TAN 420E, Geldanamycin, Herbimycin B
CAS Number70563-58-5
Molecular FormulaC30H42N2O9
Molecular Weight574.7
SourceStreptomyces sp.
Purity>99% by HPLC
FormSupplied as a yellow lyophillized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesHerbimycin, Antibiotic TAN 420F


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