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You are here:Home » Antibodies » Abs to Chromatin Proteins » Anti -Heterochromatin Protein 1 gamma, (CBX3, chromobox homolog 3 (HP1 gamma homolog, Drosophila) , HGNC:1553, HECH, HP1-GAMMA, HP1Hs-gamma , HP1 gamma homolog, chromobox homolog 3, chromobox homolog 3 (Drosophila HP1 gamma), heterochromatin protein HP1 gamma,

Anti -Heterochromatin Protein 1 gamma, (CBX3, chromobox homolog 3 (HP1 gamma homolog,
Drosophila) , HGNC:1553, HECH, HP1-GAMMA, HP1Hs-gamma , HP1 gamma homolog, chromobox
homolog 3, chromobox homolog 3 (Drosophila HP1 gamma), heterochromatin protein HP1 gamma,

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B IH
CBX3 seems to be involved in transcriptional silencing in heterochromatin-like complexes. It recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. It may contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). In addition, it is involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Catalog #H2034-52D
ApplicationsSuitable for use in Peptide ELISA, Western Blot and Immunohistochemistry. Optimal dilutions to be determined by the researcher.
Recommended Dilutions
Peptide ELISA: Detection limit dilution 1:32,000
Western Blot: 0.3-1.0 ug/ml. ~20kD band observed in lysates of A431, HeLa, HepG2, NIH3T3 and NSO. (calculated MW of 20.8kD according to NP_009207.2 and NP_057671.2).
Immunohistochemistry (Paraffin): 2-3ug/ml shows strong nuclear staining in trophoblasts
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to aa C-EAFLNSQKAGKEKD,
from the internal region of human Heterochromatin Protein 1 gamma (NP_009207.2, NP_057671.2)
SpecificityRecognizes human Heterochromatin Protein 1 gamma. No cross-reactivity expected with HP1-alpha and HP1-beta.
Species crossreactivityMouse. Species sequence homology: rat, canine
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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