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Anti -HINT1 (Histidine Triad Nucleotide-binding Protein 1, Adenosine 5'-Monophosphoramidase, Protein Kinase C Inhibitor 1, Protein Kinase C-interacting Protein 1, PKCI-1, HINT, PKCI1, PRKCNH1)
Anti -HINT1 (Histidine Triad Nucleotide-binding Protein 1, Adenosine
5'-Monophosphoramidase, Protein Kinase C Inhibitor 1, Protein Kinase C-interacting Protein
1, PKCI-1, HINT, PKCI1, PRKCNH1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IH |
|
| Histidine triad nucleotide-binding protein 1 (HINT1) is a member of the histidine triad (HIT) protein family, a group of small nucleotide-binding and –hydrolyzing proteins. HINT1 interacts with several diverse proteins and has been suggested to have tumor suppressive activities. HINT1 catalyzes the hydrolysis of adenosine 5'-monophoramidate substrates such as AMP-morpholidate, but its enzymatic function does not appear to play a role in its tumor suppression. Recent experiments demonstrate that HINT1 forms a complex with POSH and JNK in vivo, inhibiting AP-1 activity and the phosphorylation of c-Jun, and this action could contribute to the tumor suppressor activity of HINT1. Other studies raise the possibility of HINT1 as a candidate gene for schizophrenia. | | | Catalog # | H4014-01 | | Applications | Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1-2ug/ml | | Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, 0.02% sodium azide. | | | Purity | Purified by immunoaffinity chromatography. | | | Immunogen | Synthetic peptide corresponding to 17aa in human HINT1. | | Specificity | Recognizes human HINT1. Species sequence homology: Mouse, rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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