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You are here:Home » Antibodies » Abs to Histones » Anti -HIRA (HIR Histone Cell Cycle Regulation Defective Homolog A (S. cerevisiae), HIR, DGCR1, Protein HIRA, TUP1-like Enhancer of Split Protein 1, TUP1, TUPLE1)

Anti -HIRA (HIR Histone Cell Cycle Regulation Defective Homolog A (S. cerevisiae), HIR,
DGCR1, Protein HIRA, TUP1-like Enhancer of Split Protein 1, TUP1, TUPLE1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified E B
HIRA is a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this protein in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. It plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate protein in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.
Catalog #H4078
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:1,000
Western Blot: 1:50-1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.09% sodium azide.
PurityPurified by ammonium sulfate precipitation.
ImmunogenSynthetic peptide selected from the Center region of human HIRA (KLH).
SpecificityRecognizes human HIRA.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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