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Anti -Histone H2A.X (H2A Histone Family Member X, H2A.FX, H2A/X, H2AFX, H2AX, H2A.X)
Anti -Histone H2A.X (H2A Histone Family Member X, H2A.FX, H2A/X, H2AFX, H2AX, H2A.X)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IP |
|
| H2AX is involved in DNA repair and the maintenance of genomic stability, although its precise role is still to be defined. H2AX is phosphorylated soon after the appearance of double-stranded breaks, and has been implicated both in homologous recombination and nonhomologous end joining DNA repair pathways. H2AX is thought to have a critical function in the recruitment of DNA repair factors and DNA damage-signaling proteins. Hyperphoshorylation of H2AX may be linked to chromatin fragmentation prior to apoptosis. | | | Catalog # | H5110-03R | | Applications | Suitable for use in Immunoprecipitation and Western Blot. Other applications not tested. | | Recommended Dilutions | Immunoprecipitation: 5ug-20ug/mg protein | | Western Blot: 1:5000-1:15,000. Band at ~15kD in nuclear extracts from human 293T cells. | | Optimal dilutions to be determined by the researcher. | | Control Peptide | H5110-03T: Histone H2A.X, Control Peptide, Human | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in Tris-citrate/phosphate, pH 7.5, 0.09% sodium azide. | | Purity | Purified by affinity chromatography. | | Immunogen | Synthetic peptide corresponding to a region within the C-terminus of human H2AX (locus link ID 3014). | | Specificity | Recognizes human Histone H2AX. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Hist5.2ax, Histone 2AX, Histone H2AX, Histone H2AFX, Histone H2A.X, Histone H2A/X |
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