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You are here:Home » Antibodies » Abs to Histones » Anti -Histone H2A.X (H2A Histone Family Member X, H2A.FX, H2A/X, H2AFX, H2AX, H2A.X)

Anti -Histone H2A.X (H2A Histone Family Member X, H2A.FX, H2A/X, H2AFX, H2AX, H2A.X)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP
H2AX is involved in DNA repair and the maintenance of genomic stability, although its precise role is still to be defined. H2AX is phosphorylated soon after the appearance of double-stranded breaks, and has been implicated both in homologous recombination and nonhomologous end joining DNA repair pathways. H2AX is thought to have a critical function in the recruitment of DNA repair factors and DNA damage-signaling proteins. Hyperphoshorylation of H2AX may be linked to chromatin fragmentation prior to apoptosis.
Catalog #H5110-03R
ApplicationsSuitable for use in Immunoprecipitation and Western Blot. Other applications not tested.
Recommended DilutionsImmunoprecipitation: 5ug-20ug/mg protein
Western Blot: 1:5000-1:15,000. Band at ~15kD in nuclear extracts from human 293T cells.
Optimal dilutions to be determined by the researcher.
Control PeptideH5110-03T: Histone H2A.X, Control Peptide, Human
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in Tris-citrate/phosphate, pH 7.5, 0.09% sodium azide.
PurityPurified by affinity chromatography.
ImmunogenSynthetic peptide corresponding to a region within the C-terminus of human H2AX (locus link ID 3014).
SpecificityRecognizes human Histone H2AX.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesHist5.2ax, Histone 2AX, Histone H2AX, Histone H2AFX, Histone H2A.X, Histone H2A/X


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