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Anti -Histone H2A.X (H2A Histone Family Member X, H2A.FX, H2A/X, H2AFX, H2AX)
Anti -Histone H2A.X (H2A Histone Family Member X, H2A.FX, H2A/X, H2AFX, H2AX)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IH IF |
|
| H2A.X is involved in DNA repair and the maintenance of genomic stability, although its precise role is still to be defined. H2AX is phosphorylated soon after the appearance of double-stranded breaks and has been implicated both in homologous recombination and nonhomologous end joining DNA repair pathways. H2AX is thought to have a critical function in the recruitment of DNA repair factors and DNA damage-signaling proteins. Hyperphoshorylation of H2AX may be linked to chromatin fragmentation prior to apoptosis. | | | Catalog # | H5110-03V | | Applications | Suitable for use in Immunofluorescence, Western Blot, and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunofluorescence: 1:100-1:200 | | Western Blot: 1:500-1:1,000 | | Immunohistochemistry: 1:50-1:100 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic non-phosphopeptide corresponding to human Histone H2A.X around the phosphorylation site of serine 139 (Q-A-SP-Q-E). | | Specificity | Recognizes human Histone H2AX. Species Cross-Reactivity: mouse, rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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