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You are here:Home » Antibodies » Abs to Histones » Anti -Histone H2A.X (H2A Histone Family Member X, H2A.FX, H2A/X, H2AFX, H2AX)

Anti -Histone H2A.X (H2A Histone Family Member X, H2A.FX, H2A/X, H2AFX, H2AX)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH IF
H2A.X is involved in DNA repair and the maintenance of genomic stability, although its precise role is still to be defined. H2AX is phosphorylated soon after the appearance of double-stranded breaks and has been implicated both in homologous recombination and nonhomologous end joining DNA repair pathways. H2AX is thought to have a critical function in the recruitment of DNA repair factors and DNA damage-signaling proteins. Hyperphoshorylation of H2AX may be linked to chromatin fragmentation prior to apoptosis.
Catalog #H5110-03V
ApplicationsSuitable for use in Immunofluorescence, Western Blot, and Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunofluorescence: 1:100-1:200
Western Blot: 1:500-1:1,000
Immunohistochemistry: 1:50-1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic non-phosphopeptide corresponding to human Histone H2A.X around the phosphorylation site of serine 139 (Q-A-SP-Q-E).
SpecificityRecognizes human Histone H2AX. Species Cross-Reactivity: mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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