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You are here:Home » Molecular Biology » MB-Histones » Histone H1 (F1), Lysine Rich

Histone H1 (F1), Lysine Rich


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Histones are believed to be regularly arranged in the deep groove of the DNA helix. The recurring positive charges of the histones form electrostatic associations with the negatively charged phosphate groups of DNA making the DNA more stable and flexible. This allows for the supercoiling of the chromatin fibers.
With the exception of H1, the primary structures of the calf thymus histones have been determined. Comparisons with the structures for histones from other sources indicate that the histones rank among the most highly conserved (low mutation rate) proteins in nature.
Catalog #H5110-07
Molecular Weights of HistonesLysine Rich (H1, f1): ~ 31,500
Slightly Lysine Rich (H2a, f2a2): 14,004
Slightly Lysine Rich (H2b, f2b): 13,774
Arginine Rich (H3, f3): 15,324
Arginine Rich (H4, f2a1): 11,282
DescriptionHistone subclass F1
SpecificitySDS-PAGE Analysis: Doublet at ~31kD (GE Healthcare PhastGel Homogenous 20%)
Instructions for UseMost soluble in an acidic buffer such as 0.9M acetic acid at 1mg/ml. (Some assay systems may require more or less dilute histones.) Allow sufficient time for complete dissolution. Do not store diluted histones, as they will lose activity in solution. Prepare histone solution immediately before use.
Storage and StabilityStore lyophilized histones desiccated at 4°C. Reconstitute per reconstitution instructions. Do not store reconstituted histones. Histones lose activity in solutions. Further dilutions can be made in assay buffer.
Molecular Weight31.5kD
SourceCalf thymus
FormSupplied as a white powder
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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