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You are here:Home » Antibodies » Abs to Histones » Anti -Histone H2B

Anti -Histone H2B

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B IH
Changes in chromatin structure play a key role in the regulation of transcription in eukaryotes. The nucleosome is the primary building block of chromatin, and is made up of four core histone proteins (H2A, H2B, H3 and H4. Acetylation of core histones regulates gene expression. Histone H2B is acetylated in the N-terminal region, primary at lysines 5, 12, 15, and 20. Ubiquitylation of histone H2B at lysine 123 by Rad6 has been implicated in transcriptional activation and lysine methylation on histone H3. Histone H2B phosphorylation at Ser10 (for yeast) and Ser14 (for mammalian cells) has been linked to regulation of cell apoptosis and meiosis.
Catalog #H5110-09A
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionsImmunohistochemistry: Paraformaldehyde treated sections
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid. No preservative added.
PuritySerum
ImmunogenSynthetic peptide, Histone H2B, PEPAKSAPAPKKGSKKAVTKAQK
SpecificityReacts with histone H2B in human nuclear fractions. Does not crossreact with other histones, H1, H2A, H3 or H4. Species Crossreactivity: Binding of histone H2B from other species has not been tested. Species crossreactivity is expected due to sequence homology of histone H2B appears to be identical in all species examined.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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