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You are here:Home » Antibodies » Abs to Histones » Anti -Histone H3, phosphorylated (Ser10)

Anti -Histone H3, phosphorylated (Ser10)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites E B
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3.
Catalog #H5110-13B
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:1,000
Western Blot: 1:100-1:500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No10i48
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid, 0.09% sodium azide.
PurityAscites
ImmunogenSynthetic phosphopeptide corresponding to sequences in 7-18 of human histone H3 (KLH), with Ser10 phosphorylated.
SpecificityRecognizes human Histone H3 when phosphorylated at Ser10. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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