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You are here:Home » Antibodies » Abs to Histones » Anti -Histone H3

Anti -Histone H3

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Histone H3 is of length 135aa and is essential for the formation of the highly ordered chromatin structure that has been maintained throughout evolution. H3 histone is from the central building block of the nucleosomal core. It is wrapped around a nucleosome composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). Histone modifications and variants have key roles in the activation and silencing of genes. Phosphorylation of histone H3 at serine 10 and serine 28 is involved in transcriptional activation of genes responding to stress or mitogen-stimulated signaling pathways. Histones contribute to virtually all chromosomal processes, such as gene regulation, chromosome condensation, recombination, and replication.
Catalog #H5110-24
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid, 0.025% sodium azide, 50% glycerol.
PuritySerum
ImmunogenSynthetic peptide corresponding to aa66-82 (LPFQRLVREIAQDFKTD) of human Histone H3.
SpecificityRecognizes human Histone H3. Species Crossreactivity: bovine, equine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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