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You are here:Home » Antibodies » Abs to Enzymes, Methyltransferase » Anti -Histone Methyltransferase SUV39H1

Anti -Histone Methyltransferase SUV39H1

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Human histone methyltransferase SUV39H1 is the homologue of the dominant Drosophila PEV modifier Su(var)3–9 and is composed of 412 amino acid residues (1). It combines two of the most evolutionarily conserved domains of the “chromatin regulators”: the chromo and SET domains (2,3). The 60 amino acid chromo domain represents an ancient histone-like fold that directs heterochromatic localizations. It has been demonstrated that the 130 amino acid SET domain contains the methyltransferase catalytic motif, which cooperates with the adjacent cystein-rich regions to confer histone metheytransfersase activity (1). This enzyme selectively methylates histone H3 on lysine 9, which generates a binding site for HP1 proteins, a family of heterochromatic adaptor molecules involved in both gene silencing and supra-nucleosomal chromatin structure (4,5). SUV39H1 histone methyltransferase plays in important role in modification of histone amino termini and regulation of gene expression.
Catalog #H5205
ApplicationsSuitable for use in ELISA and Western Blot.
Recommended DilutionWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Storage and Stability May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol. No preservative added.
PurityPurified by Protein A affinity chromatography.
ImmunogenSynthetic peptide (KLH coupled) corresponding to the N-terminal residue sequence of human SUV39H1.
SpecificityDetects human SUV39H1 histone methyltransferase only. It does not crossreact with other related proteins.
NoteAdherence to the attached protocol is extremely important.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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