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You are here:Home » Antibodies » Abs to Infectious Disease HIV » Anti -HIV-1 p66, Strain IIIB (Reverse Transcriptase, Human Immunodeficiency Virus-1) (HRP)

Anti -HIV-1 p66, Strain IIIB (Reverse Transcriptase, Human Immunodeficiency Virus-1) (HRP)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Highly Purified E B IH
Human immunodeficiency virus (HIV) is a retrovirusthat can lead to a condition in which the immune systembegins to fail, leading to opportunistic infections. HIV primarily infects vital cells in the humanimmune systemsuch as helper T cells(specifically CD4+ T cells), macrophagesand dendritic cells. HIV infection leads to low levels of CD4+ T cells through three main mechanisms: firstly, direct viral killing of infected cells; secondly, increased rates of apoptosisin infected cells; and thirdly, killing of infected CD4+ T cells by CD8 cytotoxic lymphocytesthat recognize infected cells. When CD4+ T cell numbers decline below a critical level, cell-mediated immunityis lost, and the body becomes progressively more susceptible to opportunistic infections. HIV was classified as a member of the genus Lentivirus, part of the family of Retroviridae. Lentiviruses have many common morphologies and biological properties. Many species are infected by lentiviruses, which are characteristically responsible for long-duration illnesses with a long incubation period. Lentiviruses are transmitted as single-stranded, positive-sense, enveloped RNA viruses. Upon entry of the target cell, the viral RNA genomeis converted to double-stranded DNAby a virally encoded reverse transcriptasethat is present in the virus particle.
Catalog #H6003-15J1
ApplicationsSuitable for use in Capture ELISA, Western Blot and Immunohistochemistry. Other applications have not been tested.
Recommended DilutionsCapture ELISA: 1:5000
Western Blot: 1:5000
Other applications have not been tested.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Labeled with horseradish peroxidase (HRP). Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. HRP conjugates are sensitive to light.
Clone TypeMonoclonal
IsotypeIgG1
Clone No5i8
HostMouse
Concentration~1mg/ml
FormSupplied as a liquid in 10mM Tris, 1% BSA, 0.02% thimerosal. Labeled with HRP. Molar Ratio: 3-4 peroxidase molecules per molecule of antibody .
Purity95%
ImmunogenHIV-1 p66 Reverse Transcriptase
SpecificityRecognizes native and recombinant HIV p66 Reverse Transcriptase.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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