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You are here:Home » Antibodies » Abs to Infectious Disease HIV » Anti -HIV-1 gp41 (Human Immunodeficiency Virus-1)

Anti -HIV-1 gp41 (Human Immunodeficiency Virus-1)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Highly Purified E B IP IH IC
Human immunodeficiency virus (HIV) is a retrovirus that can lead to a condition in which the immune system begins to fail, leading to opportunistic infections. HIV primarily infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. HIV infection leads to low levels of CD4+ T cells through three main mechanisms: firstly, direct viral killing of infected cells; secondly, increased rates of apoptosis in infected cells; and thirdly, killing of infected CD4+ T cells by CD8 cytotoxic lymphocytes that recognize infected cells. When CD4+ T cell numbers decline below a critical level, cell-mediated immunity is lost, and the body becomes progressively more susceptible to opportunistic infections. HIV was classified as a member of the genus Lentivirus, part of the family of Retroviridae. Lentiviruses have many common morphologies and biological properties. Many species are infected by lentiviruses, which are characteristically responsible for long-duration illnesses with a long incubation period. Lentiviruses are transmitted as single-stranded, positive-sense, enveloped RNA viruses. Upon entry of the target cell, the viral RNA genome is converted to double-stranded DNA by a virally encoded reverse transcriptase that is present in the virus particle.
Catalog #H6004-12F
ApplicationsSuitable for use in ELISA, Western Blot, Immunoprecipitation, Immunocytochemistry and Immunohistochemistry. Other applications not tested.
Recommended DilutionsELISA: 10-100ng/ml Depending on the amount of immobilized antigen in the assay.
Western Blot: 1-5ug/ml
Optimal dilution to be determined by researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No5i28
HostMouse
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.0. No stabilizers or preservatives added.
Purity95%
ImmunogenHigh affinity mouse HIV-1 gp41 (Human Immunodeficiency Virus-1).
SpecificityRecognizes native and recombinant gp41 HIV-1 in ELISA and Western Blot. Epitope mapped to aa730-750.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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