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Specifications

Clone Host Grade Applications Monoclonal Mouse Affinity Purified IP FC

HLA E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA E binds a restricted subset of peptides derived from the leader peptides of other class I molecules.
Catalog #	H6098-10G
Cellular Localization	Type I membrane protein.
Applications	Suitable for use in Flow Cytometry and Immunoprecipitation. Other applications not tested.
Recommended Dilution	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1
Clone No	8L244
Host	Mouse
Source	Human
Concentration	As reported
Form	In TBS with 15mM Sodium Azide. pH 8.0
Purity	Purified by immunoaffinity chromatography.
Immunogen	Bacterially expressed recombinant full length protein refolded with beta2-microglobulin and peptide (Human).
Specificity	The antibody recognized native surface-expressed HLA E, but not denaturated heavy chain of HLA E. The published results showed that the antibody crossreacts with some classical MHC Class I molecules (HLA A3, A11, B7). However, the recent Workshop I Session on the 3rd International Conference on HLA-G (Paris, July 2003) confirmed that the antibody exhibits much broader crossreactivity classical MHC Class I antigens, namely with HLA A24, A32, B8, B15, B27, B35, B44, B54, C3, C4, C5 and C7. Species Crossreactivity: Crossreacts with Human.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.