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You are here:Home » Antibodies » Abs to HLA » Anti -HLA Class 1 Antigen E

Anti -HLA Class 1 Antigen E

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified IP FC
HLA E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA E binds a restricted subset of peptides derived from the leader peptides of other class I molecules.
Catalog #H6098-10G
Cellular Localization Type I membrane protein.
ApplicationsSuitable for use in Flow Cytometry and Immunoprecipitation. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No8L244
HostMouse
SourceHuman
ConcentrationAs reported
FormIn TBS with 15mM Sodium Azide. pH 8.0
PurityPurified by immunoaffinity chromatography.
ImmunogenBacterially expressed recombinant full length protein refolded with beta2-microglobulin and peptide (Human).
SpecificityThe antibody recognized native surface-expressed HLA E, but not denaturated heavy chain of HLA E. The published results showed that the antibody crossreacts with some classical MHC Class I molecules (HLA A3, A11, B7). However, the recent Workshop I Session on the 3rd International Conference on HLA-G (Paris, July 2003) confirmed that the antibody exhibits much broader crossreactivity classical MHC Class I antigens, namely with HLA A24, A32, B8, B15, B27, B35, B44, B54, C3, C4, C5 and C7. Species Crossreactivity: Crossreacts with Human.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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