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You are here:Home » Antibodies » Abs to HLA » Anti -HLA-DRA (HLA Class II Histocompatibility Antigen, DR alpha Chain, MHC Class II Antigen DRA, HLA-DRA1) (APC)

Anti -HLA-DRA (HLA Class II Histocompatibility Antigen, DR alpha Chain, MHC Class II
Antigen DRA, HLA-DRA1) (APC)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified FC
HLA-DR is a transmembrane human major histocompatibility complex 2 (MHC II) family member, which consists of a 34kD (alpha) subunit and one of several 28kD (beta) subunits. HLA-DR is expressed primarily by B cells and dendritic cells (DC), where it binds peptides derived from internalized and processed antigenic proteins. It presents these peptides on the cell surface for recognition by the T cell receptor on CD4T cells. This interaction is central to antigen specificity in the adaptive immune response. HLA-DR alleles, polymorphisms, and aberrant expression are linked to a variety of diseases including autoimmunity and cancer.
Catalog #H6098-71D
ApplicationsSuitable for use in Flow Cytometry. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
HybridomaFusion of a mouse myeloma with B cells obtained from a mouse immunized with HLA-DR expressing RPMI8866 cells.
Storage and StabilityMay be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Freezing APC conjugates will result in a substantial loss of activity. APC conjugates are sensitive to light.
Clone TypeMonoclonal
IsotypeIgG1
Clone No10K56
HostMouse
SourceHuman
Concentration100 Tests/ml
FormSupplied as a liquid in 1ml saline, 0.5% BSA, 0.1% sodium azide. Labeled with Allophycocyanin (APC).
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant human HLA-DR expressing RPMI8866 cells (Accession #P01903).
SpecificityRecognizes human HLA-DR.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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