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You are here:Home » Antibodies » Abs to HLA » Anti -HLA Class 2 Antigen DR

Anti -HLA Class 2 Antigen DR

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B FC
HLA DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of an alpha chain (36kD) and a beta chain (27kD). It is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T helper cells. They therefore have a critical role in the initiation of the immune response.
Catalog #H6099-95Y
ApplicationsSuitable for use in Flow Cytometry, ELISA and Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No8L290
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2.
PurityPurified by Protein A affinity chromatography.
ImmunogenPurified, insoluble Human DR1 beta chain (DRB1*0101) expressed in E. coli inclusion bodies.
SpecificitySpecifically binds to the empty but not peptide-loaded form of HLA-DR1 Species Crossreactivity: Reacts with Human.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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